O QUE FOI APRESENTADO
Finalidade da operação
The main objective of this research proposal is to establish the connection between the development of new bio-based packaging and micro/nanostructured systems as carriers of bioactive compounds, with the development of a new dynamic 3D in vitro intestinal cell model, aiming the bioavailability and safety assessment of the developed structured systems. To achieve this goal the following issues will be explored: 1) Production of micro/nanostructured systems bio-based with bioactive compounds and evaluation of their bioaccessibility on a dynamic in vitro GIT system (DIVGIS) model which simulated GIT digestion; 2) Development of a dynamic 3D in vitro intestine cell-based system (DIICS) platform prototype using a 3D cell culture (including enterocytes, mucus-secreting cells, M-cells and…
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The main objective of this research proposal is to establish the connection between the development of new bio-based packaging and micro/nanostructured systems as carriers of bioactive compounds, with the development of a new dynamic 3D in vitro intestinal cell model, aiming the bioavailability and safety assessment of the developed structured systems. To achieve this goal the following issues will be explored: 1) Production of micro/nanostructured systems bio-based with bioactive compounds and evaluation of their bioaccessibility on a dynamic in vitro GIT system (DIVGIS) model which simulated GIT digestion; 2) Development of a dynamic 3D in vitro intestine cell-based system (DIICS) platform prototype using a 3D cell culture (including enterocytes, mucus-secreting cells, M-cells and macrophages) suitable for delivery systems and, bioactive compounds bioavailability and cellular response (e.g., toxicity and inflammatory) assessment; 3) Exploring DIICS integration to another dynamic in vitro platform namely, a DIVGIS model, to evaluate bioavailability and toxicity of micro/nanostructured systems incorporating bioactive compounds. The proposed research project results will be a highly beneficial contribution to the state-of-the-art progress in the food sector namely on bioactive compounds-loaded micro/nanostructured systems’ bioavailability and digestibility based on dynamic in vitro solutions by gathering fundamental data on processing and safety.
PROGRAMA E OBJETIVOS
Como a operação está enquadrada
- Programa
- Programa Inovação e Transição Digital
- Fundo
- Fundo Europeu de Desenvolvimento Regional
- Objetivo estratégico
- + Inteligente
- Objetivo específico
- Reforçar a investigação, inovação e adoção de tecnologias avançadas.
- Área temática
- Investigação, Desenvolvimento e Inovação
- Atividade económica
- Investigação e desenvolvimento em biotecnologia
- Modalidade
- Subvenção
- Taxa de cofinanciamento
- 85%
ONDE
Distribuição territorial publicada
Localização observada no ficheiro de 31 de agosto de 2026.
QUANDO
Calendário publicado
- Início previsto
- 1 de outubro de 2025
- Início efetivo
- 24 de julho de 2026
- Conclusão prevista
- 29 de setembro de 2028
- Conclusão efetiva
- Não indicada