O QUE FOI APRESENTADO
Finalidade da operação
PROJECT OBJECTIVES This interdisciplinary project seeks to achieve the following: i) Compile a comprehensive collection of mycobacteria obtained from patients and household water sources, which will be integrated into the University of Coimbra Bacterial Culture Collection for wider scientific utilization. ii) Investigate the dysbiotic alterations in the gut microbiome of NTM patients resulting from NTM infection and prolonged antibiotic treatment, aiming to devise innovative strategies for restoring microbial balance. iii) Analyze the immune status of NTM patients and conduct genome sequencing to identify immune-related and genetic factors influencing susceptibility to NTM infection, providing insights into exposure risks. iv) Assess the impact of chronic NTM ingestion on mice,…
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PROJECT OBJECTIVES This interdisciplinary project seeks to achieve the following: i) Compile a comprehensive collection of mycobacteria obtained from patients and household water sources, which will be integrated into the University of Coimbra Bacterial Culture Collection for wider scientific utilization. ii) Investigate the dysbiotic alterations in the gut microbiome of NTM patients resulting from NTM infection and prolonged antibiotic treatment, aiming to devise innovative strategies for restoring microbial balance. iii) Analyze the immune status of NTM patients and conduct genome sequencing to identify immune-related and genetic factors influencing susceptibility to NTM infection, providing insights into exposure risks. iv) Assess the impact of chronic NTM ingestion on mice, particularly on intestinal and systemic immune responses, to elucidate the causal links with chronic inflammatory conditions and leaky gut conditions. v) Compile essential data to advocate for the implementation of monitoring and control measures by public health authorities to mitigate NTM exposure in municipal water systems.
PROGRAMA E OBJETIVOS
Como a operação está enquadrada
- Programa
- Programa Inovação e Transição Digital
- Fundo
- Fundo Europeu de Desenvolvimento Regional
- Objetivo estratégico
- + Inteligente
- Objetivo específico
- Reforçar a investigação, inovação e adoção de tecnologias avançadas.
- Área temática
- Investigação, Desenvolvimento e Inovação
- Atividade económica
- Investigação e desenvolvimento em biotecnologia
- Modalidade
- Subvenção
- Taxa de cofinanciamento
- 85%
ONDE
Distribuição territorial publicada
Localização observada no ficheiro de 30 de junho de 2026.
QUANDO
Calendário publicado
- Início previsto
- 1 de setembro de 2025
- Início efetivo
- 24 de abril de 2026
- Conclusão prevista
- 30 de agosto de 2028
- Conclusão efetiva
- Não indicada